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This is VAERS ID 460432

Case Details

VAERS ID: 460432 (history)  
Form: Version 1.0  
Age: 1.28  
Sex: Female  
Location: New Jersey  
Vaccinated:2012-07-16
Onset:2012-07-22
   Days after vaccination:6
Submitted: 2012-07-27
   Days after onset:5
Entered: 2012-07-27
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
HEPA: HEP A (VAQTA) / MERCK & CO. INC. 02771AE / 1 UN / UN
MMR: MEASLES + MUMPS + RUBELLA (MMR II) / MERCK & CO. INC. 1577 / 1 UN / UN
PNC13: PNEUMO (PREVNAR13) / PFIZER/WYETH E56178 / UNK UN / UN

Administered by: Private       Purchased by: Other
Symptoms: Acidosis, Acute myeloid leukaemia, Anaemia, Aspiration bone marrow abnormal, Bacterial test negative, Bilevel positive airway pressure, Blast cells present, Blood culture, Central venous catheterisation, Culture urine, Death, Diarrhoea, Endotracheal intubation, Full blood count abnormal, Hypercapnia, Leukocytosis, Mechanical ventilation, Oxygen saturation decreased, Postoperative respiratory distress, Pyrexia, Tachycardia, Tachypnoea, Thrombocytopenia, Vomiting
SMQs:, Anaphylactic reaction (broad), Acute pancreatitis (broad), Angioedema (broad), Asthma/bronchospasm (broad), Haematopoietic cytopenias affecting more than one type of blood cell (broad), Haematopoietic erythropenia (broad), Haematopoietic leukopenia (broad), Haematopoietic thrombocytopenia (narrow), Lactic acidosis (broad), Hyperglycaemia/new onset diabetes mellitus (broad), Neuroleptic malignant syndrome (broad), Systemic lupus erythematosus (broad), Anticholinergic syndrome (broad), Arrhythmia related investigations, signs and symptoms (broad), Pseudomembranous colitis (broad), Embolic and thrombotic events, venous (narrow), Blood premalignant disorders (narrow), Acute central respiratory depression (broad), Gastrointestinal nonspecific symptoms and therapeutic procedures (narrow), Eosinophilic pneumonia (broad), Malignant lymphomas (broad), Myelodysplastic syndrome (broad), Noninfectious diarrhoea (narrow), Tumour lysis syndrome (broad), Respiratory failure (narrow), Drug reaction with eosinophilia and systemic symptoms syndrome (broad), Haematological malignant tumours (narrow), Infective pneumonia (broad), Dehydration (broad)

Life Threatening? No
Birth Defect? No
Died? Yes
   Date died: 2012-07-22
   Days after onset: 0
Permanent Disability? No
Recovered? No
Office Visit? No
ER Visit? No
ER or Doctor Visit? No
Hospitalized? Yes, ? days
   Extended hospital stay? No
Previous Vaccinations:
Other Medications: (all medications received between admission 7/17/12 and death 7/22/12); Aluminum hydroxide suspension; Diphenhydramine; Acetaminophen; Propofol; Allopurinol; Cefepime; Ondansetron; Cytarabine; Morphine; Dexamethasone; Albuterol (inhaled); D
Current Illness: AML
Preexisting Conditions:
Allergies:
Diagnostic Lab Data: Autopsy is pending
CDC Split Type:

Write-up: The patient had a screening CBC done the same day as vaccinations (7/16/12) that showed leukocytosis with blasts, anemia and thrombocytopenia. She was admitted to the hospital on 7/17/12. On 7/19/12, she was diagnosed with AML by bone marrow aspirate. She also started having fever and was started on broad spectrum antibiotics. Had surgical placement of CVC on 7/20/12 and received intrathecal cytarabine. She had postoperative respiratory issues, which was treated with high flow nasal cannula oxygen and diuretics. On 7/21/12, she received dexamethasone, cytarabine, daunorubicin and etoposide. Bortezomib (a tyrosine kinase inhibitor) was given per experimental treatment protocol. Beginning 7/21/12, she developed vomiting, diarrhea, tachypnea and tachycardia with worsening desaturations. She progressed over the course of the day on 7/22/12 despite increasing respiratory support from high flow nasal cannula oxygen to bilevel positive airway pressure, to endotracheal intubation with mechanical ventilation. The team caring for her was unable to increase oxygenation, improve carbon dioxide retention or correct acidosis. The patient died on 7/22/12 at 2151. Cultures from blood and urine did not grow bacteria. An autopsy is being done.


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