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This is VAERS ID 475315

Case Details

VAERS ID: 475315 (history)  
Form: Version 1.0  
Age: 49.0  
Sex: Male  
Location: Unknown  
Submitted: 2012-11-26
Entered: 2012-11-27
   Days after submission:1
Vaccin­ation / Manu­facturer Lot / Dose Site / Route

Administered by: Unknown       Purchased by: Unknown
Symptoms: Autopsy, Death, Glioblastoma multiforme, Hyporeflexia, Immunoglobulin therapy, Metastases to meninges, Motor dysfunction, Muscular weakness, Myelitis transverse, Nuclear magnetic resonance imaging spinal cord abnormal, Paraesthesia, Respiratory disorder, Viral infection
SMQs:, Rhabdomyolysis/myopathy (broad), Peripheral neuropathy (broad), Akathisia (broad), Dyskinesia (broad), Dystonia (broad), Parkinson-like events (broad), Acute central respiratory depression (broad), Guillain-Barre syndrome (broad), Noninfectious encephalopathy/delirium (broad), Demyelination (narrow), Respiratory failure (broad), Non-haematological malignant tumours (narrow), Immune-mediated/autoimmune disorders (narrow)

Life Threatening? No
Birth Defect? No
Died? Yes
   Date died: 0000-00-00
Permanent Disability? No
Recovered? No
Office Visit? No
ER Visit? No
ER or Doctor Visit? No
Hospitalized? No
Previous Vaccinations:
Other Medications:
Current Illness:
Preexisting Conditions:
Diagnostic Lab Data:
CDC Split Type: 2012033954

Write-up: This literature report (initial receipt: 13-Nov-2012) concerns a 49-year-old male patient. The patient had a recent history of viral infection status post flu vaccination (manufacturer, brand name and batch number were not provided). On an unknown date (post viral infection) the patient presented with a 2-week history of bilateral lower extremity weakness and paresthesias starting at the level of the axilla. He was evaluated by Neurology and initially diagnosed with transverse myelitis. He underwent intravenous immunoglobulin and steroid treatment without improvement. The patient''s physical examination revealed 3/5 proximal and 5/5 distal muscle strength in the lower extremities, deep tendon reflexes were 2/4 with no upper motor neuron signs visualized. He was medically stabilized and transferred to inpatient rehabilitation facility. Ten days post admission, the patient experienced acute motor loss (0/5) in bilateral lower extremities and worsening paresthesias, now involving bilateral upper extremities. At 10 days post admission, imaging revealed C7 to T2 diffuse cord expansion and an oval-shaped focus of intramedullary enhancement. Prior to the completion of his medical work-up, the patient passed away due to unclear causes. Death was most likely related to respiratory compromise. Post mortem autopsy results showed histopathological diagnosis of primary glioblastoma multiforme of the spinal cord. Reporter''s comment: This is a rare documented case of primary spinal glioblastoma multiforme in an adult patient. Mean survival time after onset is between 6-16 months. The major cause of death is leptomeningeal spread and cerebral metastasis. Cervical glioblastoma multiforme may have an even poorer outcome because of early involvement of the phrenic nerve nucleus and vasomotor centers.

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