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Life Threatening? No
Write-up: This case was reported in a literature article and described the occurrence of glioblastoma multiforme in a 49-year-old male subject who was vaccinated with influenza vaccine unspecified (manufacturer unspecified). On an unspecified date the subject received unspecified dose of Influenza vaccine unspecified (unknown route, unknown lot number). At an unspecified time after vaccination with Influenza vaccine unspecified, the subject presented with a 2-week history of bilateral lower extremity weakness and paresthesia starting at the level of the axilla. The subject had a recent history of viral infection status post flu vaccination. He was evaluated by Neurology and initially diagnosed with transverse myelitis. He underwent intravenous immunoglobulin and steroid treatment without improvement. The subject''s physical examination revealed 3/5 proximal and 5/5 distal muscle strength in the lower extremities, deep tendon reflexes were 2/4 with no upper motor neuron signs visualized. He was medically stabilized and transferred to our inpatient rehabilitation facility. Ten days post admission, the subject experienced acute motor loss (0/5) in bilateral lower extremities and worsening paresthesia, now involving bilateral upper extremities. At 10 days post admission, imaging revealed C7 to T2 diffuse cord expansion and an oval-shaped focus of intramedullary enhancement. Prior to the completion of his medical work-up the subject passed away due to unclear causes. The subject died from glioblastoma multiforme and respiratory failure. Post mortem autopsy results showed histopathological diagnosis of primary glioblastoma multiforme of the spinal cord.
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