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Life Threatening? Yes
Write-up: This is a concern given the timing of the onset of the second disease. There is no proof of any association but I feel that the condition is so rare that the timing of the Zostavax vaccination needs to be at least mentioned. The patient and her husband received Zostavax injections in Nov 2012. The patient developed a small localized erythematous reaction but her husband developed a full shingles reaction/rash to his right forehead which then cleared without event. In late January 2012 the patient started coming in with complaints about fullness in her ears, sinus congestion. She was treated with antibiotics and finally prednisone. While on prednisone she started to develop neurologic deficits in 3-15-13 that eventually progressed into major neurologic deficits and finally the diagnosis of Creutzfeld-Jacob Disease via MRI, EEG, and CSF evaluation. The patient is receiving comfort care at home as I write this and is expected to die within the next week. I am just concerned about the timing of the vaccination and then onset of symptoms and then diagnosis of CJD within 5 months.
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