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This is VAERS ID 489579

Case Details

VAERS ID: 489579 (history)  
Form: Version 1.0  
Age: 68.0  
Sex: Female  
Location: Wyoming  
Vaccinated:2012-11-21
Onset:2013-03-15
   Days after vaccination:114
Submitted: 2013-04-18
   Days after onset:34
Entered: 2013-04-18
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
VARZOS: ZOSTER LIVE (ZOSTAVAX) / MERCK & CO. INC. H018093 / 1 RA / SC

Administered by: Private       Purchased by: Private
Symptoms: CSF test abnormal, Creutzfeldt-Jakob disease, Ear congestion, Electroencephalogram abnormal, Erythema, Neurological symptom, Nuclear magnetic resonance imaging abnormal, Sinus congestion, Terminal state
SMQs:, Anaphylactic reaction (broad), Dementia (narrow), Guillain-Barre syndrome (broad), Noninfectious encephalitis (broad), Noninfectious encephalopathy/delirium (broad), Hypersensitivity (broad), Drug reaction with eosinophilia and systemic symptoms syndrome (broad), Opportunistic infections (broad)

Life Threatening? Yes
Birth Defect? No
Died? Yes
   Date died: 2013-04-25
   Days after onset: 41
Permanent Disability? No
Recovered? No
Office Visit? No
ER Visit? No
ER or Doctor Visit? No
Hospitalized? Yes, 3 days
   Extended hospital stay? No
Previous Vaccinations:
Other Medications: Albuterol, Fluticasone nasal spray, glucosamine, B complex vitamin, Levothyroxine, Lipitor, Omega-3 FA, Singulair, Zyrtec
Current Illness: No
Preexisting Conditions: Hyperlipidemia
Allergies:
Diagnostic Lab Data: MRI, EEG, CSF evaluation all diagnostic of Creutzfeld Jacob Disease.
CDC Split Type:

Write-up: This is a concern given the timing of the onset of the second disease. There is no proof of any association but I feel that the condition is so rare that the timing of the Zostavax vaccination needs to be at least mentioned. The patient and her husband received Zostavax injections in Nov 2012. The patient developed a small localized erythematous reaction but her husband developed a full shingles reaction/rash to his right forehead which then cleared without event. In late January 2012 the patient started coming in with complaints about fullness in her ears, sinus congestion. She was treated with antibiotics and finally prednisone. While on prednisone she started to develop neurologic deficits in 3-15-13 that eventually progressed into major neurologic deficits and finally the diagnosis of Creutzfeld-Jacob Disease via MRI, EEG, and CSF evaluation. The patient is receiving comfort care at home as I write this and is expected to die within the next week. I am just concerned about the timing of the vaccination and then onset of symptoms and then diagnosis of CJD within 5 months.


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