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This is VAERS ID 839595

History of Changes from the VAERS Wayback Machine

First Appeared on 2/14/2020

VAERS ID: 839595
VAERS Form:2
Age:
Sex:Female
Location:Foreign
Vaccinated:0000-00-00
Onset:0000-00-00
Submitted:0000-00-00
Entered:2019-10-10
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
FLUX: INFLUENZA (SEASONAL) (NO BRAND NAME) / UNKNOWN MANUFACTURER - / UNK - / -

Administered by: Other      Purchased by: ??
Symptoms: Albuminuria, Albumin urine present, Anaemia, Beta 2 microglobulin increased, Blood immunoglobulin G increased, C-reactive protein increased, Chest X-ray abnormal, Condition aggravated, Cough, Death, Electrophoresis protein abnormal, Haemoglobin decreased, Hypogammaglobulinaemia, Plasma cell myeloma, Platelet count decreased, Pleural effusion, Pneumonia, Proteinuria, Pyrexia, Rales, Thrombocytopenia, Protein urine present, Cognitive disorder, Computerised tomogram thorax abnormal, Light chain analysis decreased, Light chain analysis abnormal, Immunology test, Immunoglobulin therapy

Life Threatening? No
Birth Defect? No
Died? Yes
   Date died:0000-00-00
Permanent Disability? No
Recovered? No
Office Visit (V2.0)? No
ER or Office Visit (V1.0)? No
ER or ED Visit (V2.0)? No
Hospitalized? Yes, days:     Extended hospital stay? No
Previous Vaccinations:
Other Medications:
Current Illness: Cognitive disorder
Preexisting Conditions:
Allergies:
Diagnostic Lab Data: Test Name: Albumin urine; Result Unstructured Data: Test Result: 288, Test Result Unit: mg/day; Test Name: B2 microglobulin; Test Result: 2 mg/dl; Test Name: Immunoglobulin G; Test Result: 310 mg/dl; Test Name: Chest X-ray; Result Unstructured Data: Test Result: see text, Test Result Unit: unknown; Test Name: Computerized tomography; Result Unstructured Data: Test Result: see text, Test Result Unit: unknown; Test Name: C-reactive protein; Result Unstructured Data: Test Result: 121, Test Result Unit: mg/litre; Test Name: Serum protein electrophoresis; Result Unstructured Data: Test Result: hypogammaglobulinemia, Test Result Unit: unknown; Test Name: Hemoglobin; Result Unstructured Data: Test Result: 9.4, Test Result Unit: g/dL; Test Name: Immunofixation; Result Unstructured Data: Test Result: see text, Test Result Unit: unknown; Test Name: Kappa/Lambda light chain ratio; Result Unstructured Data: Test Result: 4.95 (with absence of lambda chains in the urines), Test Result Unit: unknown; Test Name: Lambda light chain analysis; Test Result: 39 mg/dl; Test Name: Physical examination; Result Unstructured Data: Test Result: see text, Test Result Unit: unknown; Test Name: Platelet count; Result Unstructured Data: Test Result: 100000, Test Result Unit: /uL; Test Name: Protein urine 24 hour; Result Unstructured Data: Test Result: 4600, Test Result Unit: mg/day
CDC 'Split Type': ITGLAXOSMITHKLINEIT2019GS

Write-up: Fever; Cough; Thrombocytopenia; Cognitive Worsening; bilateral pleural effusion; crackles on the left lung; Anaemia; Proteinuria; Albuminuria; micromolecular myeloma/Multiple Myeloma; Hypogammaglobulinemia; left pneumonia; This case was reported in a literature article and described the occurrence of multiple myeloma in a 87-year-old female patient who received Flu unspecified (Influenza vaccine) for prophylaxis. Concurrent medical conditions included cognitive disorder. On an unknown date, the patient received Influenza vaccine at an unknown dose. On an unknown date, unknown after receiving Influenza vaccine, the patient experienced multiple myeloma (serious criteria death and GSK medically significant), hypogammaglobulinemia (serious criteria GSK medically significant), pneumonia (serious criteria GSK medically significant), fever (serious criteria hospitalization), cough (serious criteria hospitalization), thrombocytopenia (serious criteria GSK medically significant), cognitive deterioration, bilateral pleural effusion, crackles lung, anemia, proteinuria and albuminuria. The patient was treated with antibiotics nos (Antibiotic Therapy (Drug Name Unknown)) and immunoglobulin. On an unknown date, the outcome of the multiple myeloma was fatal and the outcome of the hypogammaglobulinemia, fever, cough, thrombocytopenia, cognitive deterioration, bilateral pleural effusion, crackles lung, anemia, proteinuria and albuminuria were unknown and the outcome of the pneumonia was recovered/resolved. The reported cause of death was multiple myeloma. The reporter considered the multiple myeloma, hypogammaglobulinemia, pneumonia, fever, cough, thrombocytopenia, cognitive deterioration, bilateral pleural effusion, crackles lung, anemia, proteinuria and albuminuria to be related to Influenza vaccine. Additional details were reported as follows: This case was reported in a literature article and described the occurrence of cognitive worsening, bilateral pleural effusion (mild), pneumonia (left); hypogammaglobulinemia and micromolecular myeloma (a rare form of multiple myeloma) in a 87-year-old female patient who was vaccinated with unspecified influenza vaccine (manufacturer unknown) for prophylaxis. The patient had the current history of the cognitive. No information on patient''s past medical or family history or concomitant condition was provided. deterioration On unspecified date, the patient had received unspecified influenza vaccine (administration route and site unspecified, dosage unknown; batch number not provided). The age of vaccination was not provided. On an unspecified date, unknown period after vaccination, the patient with an initial cognitive worsening was admitted to department for fever and cough started. On admission the patient was feverish, physical examination evidenced a mild bilateral pleural effusion, with crackles on the left lung, without significant alterations on abdomen and heart. A chest-radiography and a successive computed tomography (CT) showed a bilateral pleural effusion and a left pneumonia. At laboratory tests, the patient had mild anaemia (hemoglobin Hb 9.4 g/dl), thrombocytopenia (Platelet count 100000/ul) and elevation of C - reactive protein (CRP), (121 mg/l). The serum proteins electrophoresis showed hypogammaglobulinemia, with Immunoglobulin G (IgG), 310 mg/dl, B2 microglobulin was increased (2 mg/dl, normal value less than 0.24) and the patient had proteinuria (4600 mg/24 h; albuminuria: 288 mg/24h). They performed the serum free light chains determination with evidence of low lambda chains level (39 mg/dl, normal value more than 90) and elevation of kappa/lambda ratio (4.95, normal value less than 2.65), with absence of lambda chains in the urines; a successive serum/urine immunofixation showed a monoclonal kappa light chain component. The patient started an empirical antibiotic therapy for pneumonia and intravenous Immunoglobulin infusion. Considering the poor expectative of life and the general conditions of the patient and they decided, according with family, not to perform a bone marrow biopsy; after pneumonia resolution the patient returned home, where the patient died a month later. It was unknown, whether the patients autopsy was performed or not. As the final diagnosis was probably "micromolecular myeloma" with secretion of k light chain only, a rare form of Multiple Myeloma. The cause of death was micromolecular myeloma. This case has been considered as serious due to hospitalization and death. The author did not comment on relationship between the events and unspecified influenza vaccine. The authors stated, "A rare case of hypogammaglobulinemia in elderly age". The author concluded "The final diagnosis was probably "micromolecular myeloma", with secretion of k light chain only, a rare form of Multiple Myeloma". Lab Comments: On an unknown date lab test were performed. physical examination evidenced a mild bilateral pleural effusion, with crackles on the left lung, without significant alterations on abdomen and heart. A chest-radiography and a successive computed tomography (CT) showed a bilateral pleural effusion and a left pneumonia. a successive serum/urine immunofixation showed a monoclonal kappa light chain component. As the final diagnosis was probably "micromolecular myeloma" with secretion of k light chain only, a rare form of Multiple Myeloma.; Reported Cause(s) of Death: micromolecular myeloma

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